Hyperthermic isolated liver perfusion with melphalan and bevacizumab
نویسندگان
چکیده
منابع مشابه
Hyperthermic isolated hepatic perfusion using melphalan for patients with ocular melanoma metastatic to liver.
PURPOSE Liver metastases are the sole or life-limiting component of disease in the majority of patients with ocular melanoma who recur. Because median survival after diagnosis of liver metastases is short and no satisfactory treatment options exist, we have conducted clinical trials evaluating isolated hepatic perfusion (IHP) for patients afflicted with this condition. EXPERIMENTAL DESIGN Twe...
متن کاملIsolated limb perfusion with melphalan for melanoma.
Isolated limb perfusion with melphalan is a well-established and effective treatment for inoperable melanoma metastases of the extremities, with an overall response rate of 80% and a complete response rate of 54%. The surgical technique is complex and serious morbidity can occur, but with attention to detail major side effects can be kept to a minimum. This article reviews the technique, result...
متن کاملHyperthermic isolated limb perfusion for extremity sarcomas.
BACKGROUND The treatment options available for extremity sarcomas are amputation or limb-sparing surgery with radiation, which may incur significant morbidity and body disfigurement. Hyperthermic isolated limb perfusion (HILP) may be an attractive option in extremity sarcomas for unresectable lesions to preserve limb function and maintain quality of life. METHODS We report the outcomes of 5 p...
متن کاملAnesthesia management of patients undergoing hyperthermic isolated limb perfusion with melphalan for melanoma treatment: an analysis of 17 cases
BACKGROUND Hyperthermic isolated limb perfusion (HILP) is used for patients with intractable or extensive in-transit metastatic melanoma of the limb to deliver high concentrations of cytotoxic agents to the affected limb and offers a treatment option in a disease stage with a poor prognosis when no treatment is given. METHODS In a retrospective chart review of 17 cases, we studied the anesthe...
متن کاملSystemic toxicity after isolated limb perfusion with melphalan for melanoma.
Systemic exposure to melphalan is minimized during isolated limb perfusion (ILP) by isolating a limb from the rest of the body. Consequently, there should be no toxicity to vital organs. At present systemic toxicity after ILP has not been studied in detail. Therefore, the incidence, nature and risk factors of systemic toxicity was retrospectively studied in 368 patients who underwent a single I...
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ژورنال
عنوان ژورنال: Journal of Visceral Surgery
سال: 2013
ISSN: 1878-7886
DOI: 10.1016/j.jviscsurg.2012.10.018